Genome-scale Cell Engineering
Services
Design, build, and deliver DNA at genome-scale
Design
Computer-aided DNA and protein design, enabled by machine learning
Build
Rapid and massively-scaled assembly of really longDNAs
Deliver
Precision integration of really longDNAs into a variety of cell types
Test
Functional assays with standard and customized readouts
Publications
De novo assembly and delivery to mouse cells of a 101 kb functional human gene
Mitchell et al. | Genetics 2017
A versatile platform for locus-scale genome rewriting and verification
Brosh et al. | PNAS 2021
Germline Transmission of a Circular Human Artificial Chromosome in the Mouse
Wudzinsak et al. | bioRxiv 2022